Aloe is indigenous to Africa but it is being cultivated all over the world. The best well known and common species of aloe is of course aloe vera, but actually there over 300 other species of aloe. Aloe Vera has been used for treatments and as a remedy since ancient times. Aloe is mostly safe to use for humans both topically and orally and is reported to be non-toxic even when injected in high doses.

Aloe has been studied extensively in Japan, Russia and also in Madagascar. There is a lot of evidence that aloe is useful as a non-specific immune stimulator and immune modulator. Not only is aloe a potential adjuvant therapy for cancer, it is also valuable for patients who immune functions have been compromised by mainstream therapies.

In studies carried out in 1980 and 1981 at the Pasteur Institute in Madagascar, the researchers found out that mice given a hypodermic injection of unrefined Aloe vahombe extract were all safe against infection caused by Listeria monocytogenes, the bacteria Klebsiella pneumoniae, Yersinia pestis, Candida albicans fungus and Plasmodium berghei parasites. In 1988 it was found that aloe inhibited the metabolism of arachidonic acid. One product of this acid suppresses the activity of immune cells that are part of the body's surveillance against cells of the cancer.

An evaluation of antimetastatic properties of aloe[ usefulness in potentiating the effectiveness of chemotherapy was carried out by two Russian researchers. They found out from their research that aloe treatment contributed to a reduction of the mass of the tumor, metastasis frequency and metastatic foci at different stages of tumor progress without affecting major tumor growth, using three types of experimental tumors in rats and mice.

S.Y. Peng in another animal study found that acemannan increased sarcomabearing mice survival. Acemannan, in both highly purified and enriched forms, was administered intraperitoneally to mice to which murine sarcoma cells had been subcutaneously implanted. The invasive, highly malignant and rapidly growing sarcoma grew in 100% of implanted control animals. This resulted in in mortality in 20 to 46 days. About 40% of animals treated with acemannan at the time of implantation of the tumor cell (1.5 x 10(6) cells) survived.



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