Bone cancer is rare and accounts for less than 1% of all new tumors. Not all bone tumors are fatal in fact benign (non cancerous) abnormalities are more common than malignant ones. Most bone cancers are secondary and have been spread from another site. Primary bone cancer which starts in the bone is quite rare constituting less than one per cent of all malignant tumors. They are more common in males, especially in children and adolescents. The most common type of primary bone cancer is osteosarcoma. This type of carcinoma usually affects young adults. It can affect any bone, but the arms, legs and pelvis are more commonly affected. Other less common forms of primary bone cancer include Ewing sarcoma, malignant fibrous histiocytoma and chondrosarcoma.

Primary Bone Cancer
The causes of primary bone tumours are not known; however, adults who have Pagets disease (a bone disease) may have an increased risk.

Secondary bone cancer
Secondary bone cancer is the most common bone cancer. It is a carcinoma that starts somewhere else in the body and spreads (metastasises) to the bone. The most common cancers that spread to the bone originate in the breast, prostate, lung, kidney and thyroid.

Reticulum cell sarcoma of the bone
A cancerous tumor of the bone marrow presenting in more males than females.

Leukaemia
Cancer of the blood, which starts in the bone marrow

Symptoms of bore cancer
Symptoms tend to develop slowly and depend on the type, location, and size of the tumor. The signs and symptoms of bone cancer include: painful bones and joints, swelling of bones and joints, problems with movement, susceptibility to fractures. Less common symptoms include: unexplained weight loss, tiredness, fever and sweating.

Remember bone cancer is very rare so if you have any of these symptoms it is likely to be caused by another condition. Always see your doctor if you have for a diagnosis.

Causes
Although bone cancer does not have a clearly defined cause, researchers have identified several factors that increase the likelihood of developing these tumors. A small number of bone cancers are due to heredity.

Diagnosis
Bone cancer can present itself in any of the bones of the body, but it is diagnosed most often in the long bones of the arms and legs.

Diagnosing bone cancer involves a number of tests, including: X-rays and bone scans to show the exact location and size of the cancer (these are always done prior to biopsy), bone biopsy where a small sample of the cancer is removed from the bone and examined in the laboratory for the presence of malignant cells, Magnetic Resonance Imaging (MRI) scan similar to a CT scan but uses magnetism instead of x-rays to build three-dimensional pictures of your body.

Treatment
The treatment and prognosis of bone cancer depend upon multiple factors including the type and extent of the cancer, the patient's age and overall health status. Tumors may be treated with surgery, radiation therapy, chemotherapy, or a combination of these.

Primary bone cancers:
The tumor, surrounding bone tissue and nearby lymph nodes are surgically removed. In severe cases, the affected limb may need to be amputated, but this is rare. Treatment may also include radiotherapy (x-rays to target and kill the cancer cells) and chemotherapy (anti-cancer drugs). These may be given before surgery, to shrink the cancer and/or afterward to destroy any remaining cancer cells.

Secondary bone cancer:
Treatment depends on the treatment for the original tumor, but usually includes chemotherapy, radiotherapy or hormone therapy. Surgery may be needed to strengthen the affected bone.

Prognosis
Overall, the chance of recovery (prognosis) for bone cancers has improved significantly since the development of modern chemotherapy. The chance of recovery will depend on a variety of influences; if the cancer has spread, the type of bone cancer, the size of the tumour, location, the person's general health and other individual factors.

If the tumor is very small and localized, the five-year survival rate is close to 90 percent. If the cancer has begun to spread, however, survival becomes more difficult. The five-year survival rate is only about 60 percent, and the prognosis is poor once the cancer spreads.

Bone cancer in cats and dogs
Bone carcinoma in dogs and cats can be a challenging disorder. Osteosarcoma is by far the most common bone tumour if dogs, usually striking the leg bones of larger breeds. Chemotherapy significantly prolongs the survival of animals with osteosarcoma when used in conjunction with surgery. For dogs Cisplatin alone or in combination with doxorubicin markedly improves survival time to a median of 8-10 months with the percentage of dogs alive after11 months at 50%.

Feline Osteosarcoma unlike its canine counterpart it has a much lower rate of metastasis and longer term survival can be expected with complete excision. Median survival for cats with osteosarcoma is approximately 2 years with many cats outreaching that.



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Thyroid cancer is a fairly common malignancy which can occur in any age group especially in people who have had radiation therapy in the neck area, although it is most common after age 30 and its aggressiveness increases significantly in older patients. Thyroid cancer develops in your thyroid, a butterfly-shaped gland located at the base of your neck, just below your Adam's apple.

Types of Thyroid Cancer
Thyroid cancers are divided into papillary carcinomas, follicular carcinomas, medullary thyroid carcinomas (MTCs), anaplastic carcinomas, primary thyroid lymphomas, and primary thyroid sarcomas.

Papillary tumours account for half of all thyroid cancers in adults, it is most common in young adult females. Follicular carcinomas are less common but more likely to recur and metastasize to the regional nodes and through blood vessels into the bones, liver and lungs. Medullary carcinoma is a rare familial cancer which is completely curable if detected before it causes symptoms. The least common type of thyroid cancer is anaplastic which has a very poor prognosis. Anaplastic thyroid cancer tends to be found after it has spread and is not cured in most cases

Causes of Thyroid Cancer
Predisposing factors include; radiation exposure, prolonged thyroid stimulating hormone exposure, familial predisposition and chronic goiter.

Signs and Symptoms
The primary signs of thyroid tumors are: a painless nodule, a lump or swelling in the neck sometimes growing rapidly, a pain in the front of the neck sometimes going up to the ears, hoarseness or other voice changes that do not go away, trouble swallowing, breathing problems, a cough that continues and is not due to a cold.

Diagnosis
The first clue is usually an enlarged palpable nodule in the thyroid gland, neck, lymph nodes of the neck, or vocal chords. Tests must rule out non malignant thyroid enlargements which are much more common. Thyroid scans measure the ability of the nodules to trap isotopes in comparison to the rest of the thyroid. Other tests include CT scans, biopsy and ultrasonic scans.

Treatment
Treatment options may include surgery to remove the thyroid gland and nearby lymph nodes, chemotherapy, radiation therapy and hormone therapy. Anaplastic cancer patients
often require a tracheostomy during the treatment and treatment is much more aggressive than for other types of thyroid cancer.

Radioactive Iodine is given to the patient with thyroid cancer after their cancer has been removed because if there are any thyroid cancer cells remaining in the body then these cells will absorb and concentrate the radioactive poisonous iodine.

Prognosis
The survival rate for patients with papillary tumors which have not spread is excellent.
Medullary cancer of the thyroid is significantly less common, but has a worse prognosis.



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Liver cancer also known as primary or metastatic hepatic carcinoma is a fairly rare form of cancer in the western world (1% of all cancers) but much more common in Africa and parts of Asia (10% to 50% of all cancers). It is much more prevalent in men and incidence increases with age. Liver cancer is rapidly fatal, usually within 6 months from gastrointestinal hemorrhage, hepatic failure or metastasis.

TYPES OF LIVE CANCER
Most primary liver tumors are known as hepatomas (hepatocellular carcinoma and primary lower cell carcinoma). Some primary liver cancers originate in the bile duct and these are known as cholangiomas. Some rare liver cancers include Kupffer cell sarcoma and hepatoblastomas (which occur almost exclusively in children and are usually respectable and curable). Metastatic liver cancer is 20 times more common than primary liver cancer and after cirrhosis this is the leading form of liver related death.

SIGNS AND SYMPTOMS
Liver cancer does not normally cause symptoms until it is in an advanced stage.
Clinical effects of advanced liver cancers include:

1. A mass in the right upper side.
2. Tender, nodular liver on palpation
3. Severe pain in the epigastrium or upper right side
4. Weight loss, anorexia, weakness, fever
5. Occasional jaundice or ascites (fluid in the abdomen)

CAUSATION
The exact cause of liver cancer is unknown in adults but in children it may be a genetic disease. Adult liver carcinomas may result from environmental exposure to carcinogens such as mold, contrast media (no longer in use), androgens and oral estrogens, the hepatitis B virus or by damage to the liver due to cirrhosis caused by too much prolonged imbibing of alcohol.

DIAGNOSIS
Liver cancer is difficult to diagnose in the presence of cirrhosis, but several tests can help identify it: The combination of an imaging study (ultrasound, CT, or MRI scans) and an elevated blood level of alpha-fetoprotein will most effectively diagnose liver cancer, electrolyte studies may indicate increased sodium retention, a liver biopsy can make a definitive diagnosis.

TREATMENT
Treatments for primary liver cancer depend on the extent (stage) of the disease, age, overall health, feelings and personal preferences. Surgery is the most effective treatment for primary liver cancer, but this is not always possible due to the size or position of the tumor. Radiofrequency ablation is an option for people with small, unresectable hepatocellular tumors and for some types of metastatic liver cancers. During this procedure, the hepatic artery (the artery from which liver cancers derive their blood supply) is blocked, and chemotherapy drugs are injected between the blockage and the liver. Cryoablation may be an option for people with inoperable primary and metastatic liver cancers. Removing the whole liver and replacing it with a liver from another person is another possible form of treatment for primary liver cancer.

Even when treatments fail to provide much improvement in the liver cancer itself, pain and other signs and symptoms caused by liver cancer can be aggressively treated to improve quality of life. In general, the treatments available for children are the same as for adults, and the best approach depends on the stage and type of cancer as well as the child's age and overall health.

Cancer is second only to cardiovascular disease as the leading cause of death in the Western world. Although Cancer is primarily a disease of the elderly with more than 60% of deaths from cancer occurring in those over the age of 65, cancer can strike even the youngest of children.

Cancer appears to occur when the growth of cells in the body is out of control and cells divide too rapidly. Cancer can develop in almost any organ or tissue, such as the lung, colon, breast, skin, bones, or nerve tissue.

Most common sites are:

Prostrate 24%
Breast 13%
Lung 13%
Colon and Rectum 9%
Bladder 3%
Uterus 2.5%

The cause of Cancer is believed to be a combination of genetic factors and outside carcinogens such as tobacco, viruses, infection, asbestos, vinyl chloride, inappropriate diet.

Cancer often has no specific symptoms, so it is important that you limit your risk factors and undergo appropriate cancer screening. The signs and symptoms will depend on where the cancer is, the size of the cancer, and how much it affects the nearby organs or structures.

If a cancer spreads (metastasizes), then symptoms may appear in different parts of the body. As a cancer grows, it begins to push on nearby organs, blood vessels, and nerves. If the cancer is in a critical area, such as certain parts of the brain, even the smallest tumor can cause early symptoms.

But sometimes cancers start in places where it does not cause any symptoms until the cancer has grown quite large. Pancreatic cancers, for example, do not usually grow large enough to be felt from the outside of the body. By the time a pancreatic cancer causes these signs or symptoms, it has usually reached an advanced stage.

A cancer may also cause symptoms common to many other problems, such as; fever, fatigue and weight loss. This may be because the cancer uses up much of the body's energy or it may cause the release of substances which affect metabolism.

Some lung cancers make hormone-like substances that affect blood calcium levels, affecting nerves and muscles and causing weakness and dizziness.

It is important to know what some of the general (non-specific) signs and symptoms of cancer are, but remember that having any of these does not mean that you have cancer.

Most cancers can be treated and some cured, depending on the specific type, location, and stage. The earlier the cancer is found, the better the prognosis.

A good example of the importance of finding cancer early is melanoma skin cancer. Skin cancer can be easy to remove if it has not grown deep into the skin, and the 5-year survival rate (percentage of people living at least 5 years after diagnosis) at this stage is nearly 100%.

Screening for breast cancer with mammograms has been shown to reduce the average stage of diagnosis of breast cancer in a population. Colorectal cancer can be detected through fecal occult blood testing and colonoscopy, which reduces both colon cancer incidence and mortality, presumably through the detection and removal of pre-malignant polyps. Similarly, cervical cytology testing (using the Pap smear) leads to the identification and excision of precancerous lesions.

Testicular self-examination is recommended for men beginning at the age of 15 years to detect testicular cancer.

SIGNS and SYMPTOMS

Pain may be an early symptom with some cancers such as bone cancers or testicular cancer.

Long-term constipation, diarrhea, or a change in the size of the stool may be a sign of colon cancer.

Pain with urination, blood in the urine, or a change in bladder function (such as more frequent or less frequent urination) could be related to bladder or prostate cancer.

Skin cancers may bleed and look like sores that do not heal.

A long-lasting sore in the mouth could be an oral cancer and should be dealt with right away, especially in patients who smoke, chew tobacco, or frequently drink alcohol.

Sores on the penis or vagina may either be signs of infection or an early cancer, and should not be overlooked.

Unusual bleeding can happen in either early or advanced cancer.

Blood in the sputum (phlegm) may be a sign of lung cancer.

Blood in the stool (or a dark or black stool) could be a sign of colon or rectal cancer.

Blood in the urine may be a sign of bladder or kidney cancer.

A bloody discharge from the nipple may be a sign of breast cancer.

Many cancers can be felt through the skin, mostly in the breast, testicle, lymph nodes (glands), and the soft tissues of the body. A lump or thickening may be an early or late sign of cancer.

While they commonly have other causes, indigestion or swallowing problems may be a sign of cancer of the esophagus, stomach, or pharynx (throat).

A cough that does not go away may be a sign of lung cancer.

A cancer may be suspected for a variety of reasons, but the definitive diagnosis of most malignancies must be confirmed by histological examination of the cancerous cells by a pathologist.

TREATMENT

Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy.

Radiation therapy may be used to treat almost every type of solid tumor, including cancers of the brain, breast, cervix, larynx, lung, pancreas, prostate, skin, stomach, uterus, or soft tissue sarcomas.

Most forms of chemotherapy target all rapidly dividing cells and are not specific for cancer cells, although some degree of specificity may come from the inability of many cancer cells to repair DNA damage, while normal cells generally can.

Contemporary methods for generating an immune response against tumours include intravesical BCG immunotherapy for superficial bladder cancer, and use of interferons and other cytokines to induce an immune response in renal cell carcinoma and melanoma patients.

Pain medication, such as morphine and oxycodone, and anti-emetics, drugs to suppress nausea and vomiting, are very commonly used in patients with cancer-related symptoms. transmission and disease.

Advances in cancer research have made a vaccine designed to prevent cancer available. The vaccine protects against four HPV types, which together cause 70% of cervical cancers and 90% of genital warts.

The consensus on diet and cancer is that obesity increases the risk of developing cancer. The cancer-fighting components of food are also proving to be more numerous and varied than previously understood, so patients are increasingly being advised to consume fresh, unprocessed fruits and vegetables for maximal health benefits.